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1

Structure–activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities

Ai-Lin Liu, Hai-Di Wang, Simon MingYuen Lee, Yi-Tao Wang, Guan-Hua Du

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 191 KB

english, 2008

2

Anti-Influenza Virus Activities of Flavonoids from the Medicinal Plant Elsholtzia rugulosa

Liu, Ai-Lin, Liu, Bo, Qin, Hai-Lin, Lee, Simon, Wang, Yi-Tao, Du, Guan-Hua

Journal:

Year:

2008

Language:

english

File:

PDF, 135 KB

english, 2008

3

Novel Alkaloids from the Roots of Stemona sessilifolia

Peng Wang, Ai-Lin Liu, Zheng An, Zhi-Hong Li, Guan-Hua Du, Hai-Lin Qin

Journal:

Chemistry & Biodiversity

Year:

2007

Language:

english

File:

PDF, 103 KB

english, 2007

4

Predictions of BuChE Inhibitors Using Support Vector Machine and Naive Bayesian Classification Techniques in Drug Discovery

Fang, Jiansong, Yang, Ranyao, Gao, Li, Zhou, Dan, Yang, Shengqian, Liu, Ai-lin, Du, Guan-hua

Journal:

Journal of Chemical Information and Modeling

Year:

2013

Language:

english

File:

PDF, 1.65 MB

english, 2013

5

Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer’s Disease Agents Using Pharmacophore, 3D-QSAR, and Molecular Docking Approaches

Pang, Xiaocong, Fu, Hui, Yang, Shilun, Wang, Lin, Liu, Ai-Lin, Wu, Song, Du, Guan-Hua

Journal:

Year:

2017

Language:

english

File:

PDF, 9.40 MB

english, 2017

6

Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors

Li-Li Gong, Lian-Hua Fang, Jian-Hao Peng, Ai-Lin Liu, Guan-Hua Du

Journal:

Journal of Biotechnology

Year:

2010

Language:

english

File:

PDF, 1.02 MB

english, 2010

7

The self-assembly of catenated calix[4]arenes

Zhan-Ting Li, Guo-Zhen Ji, Shen-Dong Yuan, Ai-Lin Du, Hui Ding, Ming Wei

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 220 KB

english, 1998

8

In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: Identifying sinensetin as a novel antiangiogenesis agent

In Kei Lam, Deepa Alex, You-Hua Wang, Ping Liu, Ai-Lin Liu, Guan-Hua Du, Simon Ming Yuen Lee

Journal:

Molecular Nutrition & Food Research

Year:

2012

Language:

english

File:

PDF, 1.04 MB

english, 2012

9

3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase

Li Gao, Mian Zu, Song Wu, Ai-Lin Liu, Guan-Hua Du

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 2.20 MB

english, 2011

10

Chemical constituents of the whole plant of Elsholtzia rugulosa

Liu, Bo, Deng, An-Jun, Yu, Jin-Qian, Liu, Ai-Lin, Du, Guan-Hua, Qin, Hai-Lin

Journal:

Journal of Asian Natural Products Research

Year:

2012

Language:

english

File:

PDF, 156 KB

english, 2012

11

Self-Assembling Calix[4]arene [2]Catenanes. Preorganization, Conformation, Selectivity, and Efficiency

Li, Zhan-Ting, Ji, Guo-Zhen, Zhao, Cheng-Xue, Yuan, Shen-Dong, Ding, Hui, Huang, Chen, Du, Ai-Lin, Wei, Ming

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 336 KB

english, 1999

12

In silico Target Fishing for the Potential Targets and Molecular Mechanisms of Baicalein as an Antiparkinsonian Agent: Discovery of the Protective Effects on NMDA Receptor-Mediated Neurotoxicity

Gao, Li, Fang, Jian-Song, Bai, Xiao-Yu, Zhou, Dan, Wang, Yi-Tao, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Chemical Biology & Drug Design

Year:

2013

Language:

english

File:

PDF, 1.69 MB

english, 2013

13

In vitro Antiviral Effects and 3D QSAR Study of Resveratrol Derivatives as Potent Inhibitors of Influenza H1N1 Neuraminidase

Li, Chao, Fang, Jian-Song, Lian, Wen-Wen, Pang, Xiao-Cong, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Chemical Biology & Drug Design

Year:

2015

Language:

english

File:

PDF, 1.21 MB

english, 2015

14

Consensus models for CDK5 inhibitors in silico and their application to inhibitor discovery

Fang, Jiansong, Yang, Ranyao, Gao, Li, Yang, Shengqian, Pang, Xiaocong, Li, Chao, He, Yangyang, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Molecular Diversity

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

15

Inhibition of acetylcholinesterase by two genistein derivatives: kinetic analysis, molecular docking and molecular dynamics simulation

Fang, Jiansong, Wu, Ping, Yang, Ranyao, Gao, Li, Li, Chao, Wang, Dongmei, Wu, Song, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Acta Pharmaceutica Sinica B

Year:

2014

Language:

english

File:

PDF, 1.67 MB

english, 2014

16

Discovery of Multitarget-Directed Ligands against Alzheimer’s Disease through Systematic Prediction of Chemical–Protein Interactions

Fang, Jiansong, Li, Yongjie, Liu, Rui, Pang, Xiaocong, Li, Chao, Yang, Ranyao, He, Yangyang, Lian, Wenwen, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Journal of Chemical Information and Modeling

Year:

2015

Language:

english

File:

PDF, 2.25 MB

english, 2015

17

Discovery of the neuroprotective effects of alvespimycin by computational prioritization of potential anti-parkinson agents

Gao, Li, Zhao, Gang, Fang, Jian-Song, Yuan, Tian-Yi, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Year:

2014

Language:

english

File:

PDF, 556 KB

english, 2014

18

New Stemona alkaloids from the roots of Stemona tuberosa

Yue, Yong, Deng, An-Jun, Li, Zhi-Hong, Liu, Ai-Lin, Ma, Lin, Zhang, Zhi-Hui, Wang, Xiu-Li, Du, Gu-Hua, Qin, Hai-Lin

Journal:

Magnetic Resonance in Chemistry

Year:

2014

Language:

english

File:

PDF, 780 KB

english, 2014

19

Overexpression of miR-223 correlates with tumor metastasis and poor prognosis in patients with colorectal cancer

Li, Ze-wu, Yang, Yong-mei, Du, Lu-tao, Dong, Zhaogang, Wang, Li-li, Zhang, Xin, Zhou, Xuan-jun, Zheng, Gui-xi, Qu, Ai-lin, Wang, Chuan-xin

Journal:

Medical Oncology

Year:

2014

Language:

english

File:

PDF, 282 KB

english, 2014

20

Ameliorative effects of baicalein in MPTP-induced mouse model of Parkinson's disease: A microarray study

Gao, Li, Li, Chao, Yang, Ran-Yao, Lian, Wen-Wen, Fang, Jian-Song, Pang, Xiao-Cong, Qin, Xue-Mei, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Pharmacology Biochemistry and Behavior

Year:

2015

Language:

english

File:

PDF, 1.09 MB

english, 2015

21

Demonstration of Tightly Radiation-Controlled Molecular Switch Based on CArG Repeats byIn VivoMolecular Imaging

Hsieh, Ya-Ju, Hwu, Luen, Ke, Chien-Chih, Huang, Ai-Lin, Chen, Fu-Du, Wu, Shyh-Jong, Chen, Sharon Chia-Ju, Zhao, Yong-Hua, Liu, Ren-Shyan

Journal:

Molecular Imaging and Biology

Year:

2015

Language:

english

File:

PDF, 1.61 MB

english, 2015

22

Stemoninine-type alkaloids from the roots of Stemona sessilifolia

Wang, Peng, Liu, Ai-Lin, Li, Zhi-Hong, Du, Guan-Hua, Qin, Hai-Lin

Journal:

Journal of Asian Natural Products Research

Year:

2008

Language:

english

File:

PDF, 125 KB

english, 2008

23

In vitro Anti-Influenza Viral Activities of Constituents from Caesalpinia sappan

Liu, Ai-Lin, Shu, Shi-Hui, Qin, Hai-Lin, Lee, Simon, Wang, Yi-Tao, Du, Guan-Hua

Journal:

Year:

2009

Language:

english

File:

PDF, 118 KB

english, 2009

24

In Vitro Anti-influenza Viral Activities of Stilbenoids from the Lianas of Gnetum pendulum

Liu, Ai-Lin, Yang, Fan, Zhu, Mian, Zhou, Dan, Lin, Mao, Lee, Simon, Wang, Yi-Tao, Du, Guan-Hua

Journal:

Year:

2010

Language:

english

File:

PDF, 90 KB

english, 2010

25

DL0410 can reverse cognitive impairment, synaptic loss and reduce plaque load in APP/PS1 transgenic mice

Yang, Ran-Yao, Zhao, Gang, Wang, Dong-Mei, Pang, Xiao-Cong, Wang, Shou-Bao, Fang, Jian-Song, Li, Chao, Liu, Ai-Lin, Wu, Song, Du, Guan-Hua

Journal:

Pharmacology Biochemistry and Behavior

Year:

2015

Language:

english

File:

PDF, 3.39 MB

english, 2015

26

Discovery of Influenza A virus neuraminidase inhibitors using support vector machine and Naïve Bayesian models

Lian, Wenwen, Fang, Jiansong, Li, Chao, Pang, Xiaocong, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Molecular Diversity

Year:

2016

Language:

english

File:

PDF, 1.19 MB

english, 2016

27

Discovery of neuroprotective compounds by machine learning approaches

Fang, Jiansong, Pang, Xiaocong, Yan, Rong, Lian, Wenwen, Li, Chao, Wang, Qi, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Year:

2016

Language:

english

File:

PDF, 1.81 MB

english, 2016

28

Molecular Modeling on Berberine Derivatives toward BuChE: An Integrated Study with Quantitative Structure-Activity Relationships Models, Molecular Docking, and Molecular Dynamics Simulations

Fang, Jiansong, Pang, Xiaocong, Wu, Ping, Yan, Rong, Gao, Li, Li, Chao, Lian, Wenwen, Wang, Qi, Liu, Ai-lin, Du, Guan-hua

Journal:

Chemical Biology & Drug Design

Year:

2016

Language:

english

File:

PDF, 2.40 MB

english, 2016

29

DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Aβ-induced neuronal damage via the Akt/JNK signaling pathway

Zhou, Dan, Zhou, Wei, Song, Jun-ke, Feng, Zhang-ying, Yang, Ran-yao, Wu, Song, Wang, Lin, Liu, Ai-lin, Du, Guan-hua

Journal:

Acta Pharmacologica Sinica

Year:

2016

Language:

english

File:

PDF, 14.08 MB

english, 2016

30

A Novel Epitope from CD22 Regulates Th1 and Th17 Cell Function in Systemic Lupus Erythematosus

Yuan, Jing, Yu, Miao, Cao, Ai-Lin, Chen, Xiao, Zhang, Li-Hua, Song, You, Cheng, Xiang, Zhou, Zi-Hua, Wang, Min, Guo, He-Ping, Du, Rong, Liao, Yu-Hua, Zheng, Song Guo

Journal:

Year:

2013

Language:

english

File:

PDF, 3.76 MB

english, 2013

31

Actinomycin D synergistically enhances the cytotoxicity of CDDP on KB cells by activating P53 via decreasing P53–MDM2 complex

Wang, Lin, Pang, Xiao-Cong, Yu, Zi-Ru, Yang, Sheng-Qian, Liu, Ai-Lin, Wang, Jin-Hua, Du, Guan-Hua

Journal:

Journal of Asian Natural Products Research

Year:

2017

Language:

english

File:

PDF, 2.38 MB

english, 2017

32

Arginine vasopressin relates with spatial learning and memory in a mouse model of spinocerebellar ataxia type 3

Jiang, Hong-Bo, Du, Ai-Lin, Luo, Hai-Yang, Yang, Jun, Luo, Xiao-Qiu, Ma, Rui-Qing, Shi, Chang-He, Xu, Yu-Ming

Journal:

Year:

2017

Language:

english

File:

PDF, 997 KB

english, 2017

33

Network pharmacology-based analysis of Chinese herbal Naodesheng formula for application to Alzheimer's disease

PANG, Xiao-Cong, KANG, De, FANG, Jian-Song, ZHAO, Ying, XU, Lv-Jie, LIAN, Wen-Wen, LIU, Ai-Lin, DU, Guan-Hua

Journal:

Chinese Journal of Natural Medicines (Imprint ELSEVIER)

Year:

2018

Language:

english

File:

PDF, 2.17 MB

english, 2018

34

Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches

Kang, De, Pang, Xiaocong, Lian, Wenwen, Xu, Lvjie, Wang, Jinhua, Jia, Hao, Zhang, Baoyue, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Year:

2018

Language:

english

File:

PDF, 1.13 MB

english, 2018

35

Anti-influenza effect and action mechanisms of the chemical constituent gallocatechin-7-gallate from Pithecellobium clypearia Benth

Li, Chao, Xu, Lv-jie, Lian, Wen-wen, Pang, Xiao-cong, Jia, Hao, Liu, Ai-lin, Du, Guan-hua

Journal:

Acta Pharmacologica Sinica

Year:

2018

Language:

english

File:

PDF, 4.63 MB

english, 2018

36

The Bioinformatic Analysis of the Dysregulated Genes and MicroRNAs in Entorhinal Cortex, Hippocampus, and Blood for Alzheimer’s Disease

Pang, Xiaocong, Zhao, Ying, Wang, Jinhua, Zhou, Qimeng, Xu, Lvjie, Kang, De, Liu, Ai-Lin, Du, Guan-Hua

Journal:

BioMed Research International

Year:

2017

Language:

english

File:

PDF, 4.27 MB

english, 2017

37

Identification of Estrogen Receptor α Antagonists from Natural Products via In Vitro and In Silico Approaches

Pang, Xiaocong, Fu, Weiqi, Wang, Jinhua, Kang, De, Xu, Lvjie, Zhao, Ying, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Oxidative Medicine & Cellular Longevity

Year:

2018

Language:

english

File:

PDF, 9.27 MB

english, 2018

38

Antioxidant, Anti-Inflammatory and Anti-Influenza Properties of Components from Chaenomeles speciosa

Zhang, Li, Cheng, Yong-Xian, Liu, Ai-Lin, Wang, Hai-Di, Wang, Ya-Ling, Du, Guan-Hua

Journal:

Year:

2010

Language:

english

File:

PDF, 286 KB

english, 2010

39

Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment

Zu, Mian, Li, Chao, Fang, Jian-Song, Lian, Wen-Wen, Liu, Ai-Lin, Zheng, Li-Shu, Du, Guan-Hua

Journal:

Year:

2015

Language:

english

File:

PDF, 3.20 MB

english, 2015

40

DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice

Lian, Wenwen, Fang, Jiansong, Xu, Lvjie, Zhou, Wei, Kang, De, Xiong, Wandi, Jia, Hao, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Year:

2017

Language:

english

File:

PDF, 3.22 MB

english, 2017

41

Design, Synthesis, and Biological Evaluation of a New Series of Biphenyl/Bibenzyl Derivatives Functioning as Dual Inhibitors of Acetylcholinesterase and Butyrylcholinesterase

Wang, Dong-mei, Feng, Bo, Fu, Hui, Liu, Ai-lin, Wang, Lin, Du, Guan-hua, Wu, Song

Journal:

Year:

2017

Language:

english

File:

PDF, 5.34 MB

english, 2017

42

Effects of P-Glycoprotein on the Transport of DL0410, a Potential Multifunctional Anti-Alzheimer Agent

Pang, Xiaocong, Wang, Lin, Kang, De, Zhao, Ying, Wu, Song, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Year:

2017

Language:

english

File:

PDF, 5.50 MB

english, 2017

43

Direct observation of broadband nonclassical states in a room-temperature light–matter interface

Dou, Jian-Peng, Yang, Ai-Lin, Du, Mu-Yan, Lao, Di, Li, Hang, Pang, Xiao-Ling, Gao, Jun, Qiao, Lu-Feng, Tang, Hao, Jin, Xian-Min

Journal:

npj Quantum Information

Year:

2018

Language:

english

File:

PDF, 1.07 MB

english, 2018

44

A broadband DLCZ quantum memory in room-temperature atoms

Dou, Jian-Peng, Yang, Ai-Lin, Du, Mu-Yan, Lao, Di, Gao, Jun, Qiao, Lu-Feng, Li, Hang, Pang, Xiao-Ling, Feng, Zhen, Tang, Hao, Jin, Xian-Min

Journal:

Communications Physics

Year:

2018

Language:

english

File:

PDF, 900 KB

english, 2018

45

Design, synthesis and biological evaluation of honokiol derivatives as influenza neuraminidase inhibitors

Lin, Ding, Yi, Yang-Jie, Xiao, Meng-Wu, Chen, Jia, Ye, Jiao, Hu, Ai-Xi, Lian, Wen-Wen, Liu, Ai-Lin, Du, Guan-Hua

Journal:

Journal of Asian Natural Products Research

Year:

2018

Language:

english

File:

PDF, 1.73 MB

english, 2018

46

DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss

Zhou, Wei, Lian, Wen-wen, Yan, Rong, Jia, Hao, Xu, Lv-jie, Wang, Lin, Liu, Ai-lin, Du, Guan-hua

Journal:

Acta Pharmacologica Sinica

Year:

2019

Language:

english

File:

PDF, 4.47 MB

english, 2019

47

DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss

Zhou, Wei, Lian, Wen-wen, Yan, Rong, Jia, Hao, Xu, Lv-jie, Wang, Lin, Liu, Ai-lin, Du, Guan-hua

Journal:

Acta Pharmacologica Sinica

Year:

2019

File:

PDF, 4.47 MB

2019

48

DL0410 ameliorates cognitive disorder in SAMP8 mice by promoting mitochondrial dynamics and the NMDAR-CREB-BDNF pathway

Lian, Wen-wen, Zhou, Wei, Zhang, Bao-yue, Jia, Hao, Xu, Lv-jie, Liu, Ai-lin, Du, Guan-hua

Journal:

Acta Pharmacologica Sinica

Year:

2020

File:

PDF, 4.50 MB

2020